KEGG   Homo sapiens (human): 51520
Entry
51520             CDS       T01001                                 
Symbol
LARS1, HSPC192, ILFS1, LARS, LEURS, LEUS, LFIS, LRS, PIG44, RNTLS, cLRS, hr025Cl
Name
(RefSeq) leucyl-tRNA synthetase 1
  KO
K01869  leucyl-tRNA synthetase [EC:6.1.1.4]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00970  Aminoacyl-tRNA biosynthesis
Disease
H01367  Infantile liver failure
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   00970 Aminoacyl-tRNA biosynthesis
    51520 (LARS1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes [BR:hsa01007]
    51520 (LARS1)
  09182 Protein families: genetic information processing
   03016 Transfer RNA biogenesis [BR:hsa03016]
    51520 (LARS1)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    51520 (LARS1)
Enzymes [BR:hsa01000]
 6. Ligases
  6.1  Forming carbon-oxygen bonds
   6.1.1  Ligases forming aminoacyl-tRNA and related compounds
    6.1.1.4  leucine---tRNA ligase
     51520 (LARS1)
Amino acid related enzymes [BR:hsa01007]
 Aminoacyl-tRNA synthetase
  Class I (U)
   51520 (LARS1)
Transfer RNA biogenesis [BR:hsa03016]
 Eukaryotic type
  Aminoacyl-tRNA synthetases (AARSs)
   Multi-aminoacyl-tRNA synthetase complex (MSC)
    51520 (LARS1)
 Prokaryotic type
    51520 (LARS1)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial transcription and translation factors
   Other mitochondrial DNA transcription and translation factors
    51520 (LARS1)
SSDB
Motif
Pfam: tRNA-synt_1 Anticodon_1 tRNA-synt_1g tRNA-synt_1e
Other DBs
NCBI-GeneID: 51520
NCBI-ProteinID: NP_064502
OMIM: 151350
HGNC: 6512
Ensembl: ENSG00000133706
UniProt: Q9P2J5
Structure
Position
5:complement(146113034..146182650)
AA seq 1176 aa
MAERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLH
LGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPDE
EEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHW
LDYFPPLAIQDLKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIY
SPKDGQPCMDHDRQTGEGVGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMF
GQTNCWVRPDMKYIGFETVNGDIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGA
SLSAPLTSYKVIYVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRD
DMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVD
GFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWK
KQTSQCLKNLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIY
MAFYTVAHLLQGGNLHGQAESPLGIRPQQMTKEVWDYVFFKEAPFPKTQIAKEKLDQLKQ
EFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKS
TGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVAN
WDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAV
EGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQ
YLMEVTHDLRLRLKNYMMPAKGKKTDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFE
ANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVL
MENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGH
FSTKIEIRQGDNCDSIIRRLMKMNRGIKDLSKVKLMRFDDPLLGPRRVPVLGKEYTEKTP
ISEHAVFNVDLMSKKIHLTENGIRVDIGDTIIYLVH
NT seq 3531 nt   +upstreamnt  +downstreamnt
atggcggaaagaaaaggaacagccaaagtggactttttgaagaagattgagaaagaaatc
caacagaaatgggatactgagagagtgtttgaggtcaatgcatctaatttagagaaacag
accagcaagggcaagtattttgtaaccttcccatatccatatatgaatggacgccttcat
ttgggacacacgttttctttatccaaatgtgagtttgctgtagggtaccagcgattgaaa
ggaaaatgttgtctgtttccctttggcctgcactgtactggaatgcctattaaggcatgt
gctgataagttgaaaagagaaatagagctgtatggttgcccccctgattttccagatgaa
gaagaggaagaggaagaaaccagtgttaaaacagaagatataataattaaggataaagct
aaaggaaaaaagagtaaagctgctgctaaagctggatcttctaaataccagtggggcatt
atgaaatcccttggcctgtctgatgaagagatagtaaaattttctgaagcagaacattgg
cttgattatttcccgccactggctattcaggatttaaaaagaatgggtttgaaggtagac
tggcgtcgttccttcatcaccactgatgttaatccttactatgattcatttgtcagatgg
caatttttaacattaagagaaagaaacaaaattaaatttgggaagcggtatacaatttac
tctccgaaagatggacagccttgcatggatcatgatagacaaactggagagggtgttgga
cctcaggaatatactttactcaaattgaaggtgcttgagccatacccatctaaattaagt
ggcctgaaaggtaaaaatattttcttggtggctgctactctcagacctgagaccatgttt
gggcagacaaattgttgggttcgtcctgatatgaagtacattggatttgagacggtgaat
ggtgatatattcatctgtacccaaaaagcagccaggaatatgtcataccagggctttacc
aaagacaatggcgtggtgcctgttgttaaggaattaatgggggaggaaattcttggtgca
tcactttctgcacctttaacatcatacaaggtgatctatgttctcccaatgctaactatt
aaggaggataaaggcactggtgtggttacaagtgttccttccgactcccctgatgatatt
gctgccctcagagacttgaagaaaaagcaagccttacgagcaaaatatggaattagagat
gacatggtcttgccatttgagccggtgccagtcattgaaatcccaggttttggaaatctt
tctgctgtaaccatttgtgatgagttgaaaattcagagccagaatgaccgggaaaaactt
gcagaagcaaaggagaagatatatctaaaaggattttatgagggtatcatgttggtggat
ggatttaaaggacagaaggttcaagatgtaaagaagactattcagaaaaagatgattgac
gctggagatgcacttatttacatggaaccagagaaacaagtgatgtccaggtcgtcagat
gaatgtgttgtggctctgtgtgaccagtggtacttggattatggagaagagaattggaag
aaacagacatctcagtgcttgaagaacctggaaacattctgtgaggagaccaggaggaat
tttgaagccaccttaggttggctacaagaacatgcttgctcaagaacttatggtctaggc
actcacctgccttgggatgagcagtggctgattgaatcactttctgactccactatttac
atggcattttacacagttgcacacctattgcaggggggtaacttgcatggacaggcagag
tctccgctgggcattagaccgcaacagatgaccaaggaagtttgggattatgttttcttc
aaggaggctccatttcctaagactcagattgcaaaggaaaaattagatcagttaaagcag
gagtttgaattctggtatcctgttgatcttcgcgtctctggcaaggatcttgttccaaat
catctttcatattacctttataatcatgtggctatgtggccggaacaaagtgacaaatgg
cctacagctgtgagagcaaatggacatctcctcctgaactctgagaagatgtcaaaatcc
acaggcaacttcctcactttgacccaagctattgacaaattttcagcagatggaatgcgt
ttggctctggctgatgctggtgacactgtagaagatgccaactttgtggaagccatggca
gatgcaggtattctccgtctgtacacctgggtagagtgggtgaaagaaatggttgccaac
tgggacagcctaagaagtggtcctgccagcactttcaatgatagagtttttgccagtgaa
ttgaatgcaggaattataaaaacagatcaaaactatgaaaagatgatgtttaaagaagct
ttgaaaacagggttttttgagtttcaggccgcaaaagataagtaccgtgaattggctgtg
gaagggatgcacagagaacttgtgttccggtttattgaagttcagacacttctcctcgct
ccattctgtccacatttgtgtgagcacatctggacactcctgggaaagcctgactcaatt
atgaatgcttcatggcctgtggcaggtcctgttaatgaagttttaatacactcctcacag
tatcttatggaagtaacacatgaccttagactacgactcaagaactatatgatgccagct
aaagggaagaagactgacaaacaacccctgcagaagccctcacattgcaccatctatgtg
gcaaagaactatccaccttggcaacataccaccctgtctgttctacgtaaacactttgag
gccaataacggaaaactgcctgacaacaaagtcattgctagtgaactaggcagtatgcca
gaactgaagaaatacatgaagaaagtcatgccatttgttgccatgattaaggaaaatctg
gagaagatggggcctcgtattctggatttgcaattagaatttgatgaaaaggctgtgctt
atggagaatatagtctatctgactaattcgcttgagctagaacacatagaagtcaagttt
gcctccgaagcagaagataaaatcagggaagactgctgtcctgggaaaccacttaatgtt
tttagaatagaacctggtgtgtccgtttctctggtgaatccccagccatccaatggccac
ttctcaaccaaaattgaaatcaggcaaggagataactgtgattccataatcaggcgttta
atgaaaatgaatcgaggaattaaagacctttccaaagtgaaactgatgagatttgatgat
ccactgttggggcctcgacgagttcctgtcctgggaaaggagtacaccgagaagaccccc
atttctgagcatgctgttttcaatgtggacctcatgagcaagaaaattcatctgactgag
aatgggataagggtggatattggcgatacaataatctatctggttcattaa

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Ontology (5)   
   KEGG BRITE (5)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (66)   
   RefSeq(nuc) (6)   
   GenBank (30)   
   EMBL (30)   
3D Structure (7)   
   PDB (7)   
Protein domain (4)   
   Pfam (4)   
All databases (125)   

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